|
週次 |
日期 |
單元主題 |
|
第1週 |
09/22 |
Introduction
(第一週課程介紹，以Webax線上會議進行)
加退選結束前，若想加入會議，請mail徐老師
從會議鏈結加入
https://ntucc.webex.com/ntucc/j.php?MTID=m16e7608424770c26377c2fbf728c55cf
透過會議號加入
會議號（存取碼）： 2525 798 7989
會議密碼： 8c85kT4cv62
點選以從行動裝置加入（僅出席者）
+65-6703-6949,,25257987989## Singapore Toll |
|
第2週 |
09/29 |
Structural and Chemical Properties of Biological Macromolecules
從會議鏈結加入
https://ntucc.webex.com/ntucc/j.php?MTID=m16e7608424770c26377c2fbf728c55cf
透過會議號加入
會議號（存取碼）： 2525 798 7989
會議密碼： 8c85kT4cv62
點選以從行動裝置加入（僅出席者）
+65-6703-6949,,25257987989## Singapore Toll
透過電話加入
+65-6703-6949 Singapore Toll |
|
第3週 |
10/06 |
Protein Crystallography
從會議鏈結加入
https://ntucc.webex.com/ntucc/j.php?MTID=m16e7608424770c26377c2fbf728c55cf
透過會議號加入
會議號（存取碼）： 2525 798 7989
會議密碼： 8c85kT4cv62
點選以從行動裝置加入（僅出席者）
+65-6703-6949,,25257987989## Singapore Toll
透過電話加入
+65-6703-6949 Singapore Toll |
|
第4週 |
10/13 |
Electron Microscopy |
|
第5週 |
10/20 |
Principle of Nuclear Magnetic Resonance Spectroscopy:
(I)Biomolecular NMR technique |
|
第6週 |
10/27 |
Principle of Nuclear Magnetic Resonance Spectroscopy:
(II)Multi-dimesional NMR for protein determination |
|
第7週 |
11/03 |
Structural Bioinformatics |
|
第9週 |
11/17 |
Biophysical Methods to Probe Non-covalent Molecular Interaction (I):Circular Dichroism, UV and Fluorescence Spectroscopy |
|
第10週 |
11/24 |
Biophysical Methods to Probe Non-covalent Molecular Interaction (II):Surface Plasmon Resonance, ITC and Analytical Ultracentrifugation |
|
第11週 |
12/01 |
Structural Basis of Signal Transduction and Post-translation Modification
(農化導論) |
|
第12週 |
12/08 |
Molecular Enzymology (1. 呂岡 3. 曾譯禾 4. 賴珈玟) |
|
第13週 |
12/15 |
Protein/peptide interaction with membrane (5. 曾詠銘 6. 黃資庭 7. 陳妤嫣 8. 謝允成) |
|
第14週 |
12/22 |
Structural Features of Receptors and ligands (9. 羅中聖 10. 陳一婷 11.吳繐君 12. 廖小惟) |
|
第15週 |
12/29 |
Structural View of Protein-DNA Recognition in Gene Regulation (13. 曹捷晰 14. 林家名 15. 羅寶修 16. 黃鈺涵 ) |
|
第16週 |
01/05 |
Molecular Docking and Bioinformatics Approach:Strategies for Drug Discovery, Rational Drug Design versus Drug screen (17. 陳立 18. 鄧韻潔 19. 葉奕均 2. 莊明耀) |
|
第17週 |
01/12 |
補充課程
1. 廖小惟
Marie Wensien et al. A lysine–cysteine redox switch with an NOS bridge regulates enzyme function. Nature, 2021, doi:10.1038/s41586-021-03513-3.
2. 陳一婷
Ting-Sung Hsieh et al. Dynamic remodeling of host membranes by self-organizing bacterial effectors. Science 372, 935–941 (2021)
3. 陳妤嫣
Hayley L Knox et al. Structural basis for non-radical catalysis by TsrM, a radical SAM methylase. Nature Chemical Biology. 2021 Apr;17(4):485-491. doi: 10.1038/s41589-020-00717-y
4. 曾詠銘
Xiaojie Yang et al. Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron. Nature Chemical Biology volume 17, pages 263–271 (2021)
5. 黃鈺涵
Beth M. Hayes et al. Ticks Resist Skin Commensals with Immune Factor of Bacterial Origin. Cell 183, 1562–1571 (2020)
6. 鄧韻潔
Thomas F. Durand-Réville et al. ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii. Nature Microbiology 2, 17104 (2017)
7. 吳繐君
Lena Nasser et al. Structural basis of haem-iron acquisition by fungal pathogens. Nature Microbiology 1, 16156 (2016)
8. 羅中聖
Viktoriya Shyp et al. Reciprocal growth control by competitive binding of nucleotide second messengers to a metabolic switch in Caulobacter crescentus. Nature Microbiology 6, 59–72 (2021)
9. 葉奕均
Steven Johnson et al. Symmetry mismatch in the MS-ring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation. Nature Microbiology 5, 966–975 (2020)
10. 賴珈汶
Qiang Wang et al. Structural basis of the arbitrium peptide–AimR communication system in the phage lysis–lysogeny decision.Nature Microbiology 3, 1266–1273 (2018) |
|
第18週 |
01/19 |
補充課程
11. 林家名
Jing Zhao et al. EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction. Nature Communications 12, 986 (2021)
12. 曹捷晰
Umar Shahul Hameed et al. Structural basis for specific inhibition of the highly sensitive ShHTL7 receptor.EMBO Reprts 19, e45619 (2018)
13. 陳立
Philip Hinchliffe et al. Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes. (2016) 113 (26) E3745-E3754.
14. 曾譯禾
William R. Birmingham et al. Toward scalable biocatalytic conversion of 5-hydroxymethylfurfural by galactose oxidase using coordinated reaction and enzyme engineering. (2021) Nature Communications 12, 4946.
15.
Arjun Bhatta et al. Structural basis of RNA processing by human mitochondrial RNase P. (2021) Nature Structural & Molecular Biology 28, 713–723
16. 黃資庭
Do Hoon Kwon et al. Heat-dependent opening of TRPV1 in the presence of capsaicin. (2021) Nature Structural & Molecular Biology 28, 554–563.
17. 呂岡
Jinwoo Lee et al. Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry. (2021) Nature Structural & Molecular Biology 28, 181–189.
18. 羅寶修
Maximilian M. Sauer et al. Structural basis for broad coronavirus neutralization. (2021) Nature Structural & Molecular Biology 28, 478–486
19. 莊明耀
Wanchao Yin et al. Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin. (2021) Nature Structural & Molecular Biology 28, 319–325.
20.
Jiandong Huo et al. Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2. (2021) Nature Structural & Molecular Biology 27, 846–854.
21.
Fujiao Lv et al. An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial␣membrane. (2021) EMBO J 40:e106438
22.
Junfeng Ma et al. Structural mechanism for modulation of functional amyloid and biofilm formation by Staphylococcal Bap protein switch. (2021) EMBO J 40:e107500
23. 謝允成
Ya Peng et al. Structures of the SARS-CoV-2 nucleocapsid and their perspectives for drug design. (2020) EMBO J 39:e105938 |